Jennifer Y. Zhang

This study shows that inhibiting UBE2N in myeloid cells reduces YUMM1.7 melanoma growth by altering immune checkpoint molecules and SPP1 expression.

This study identifies osteopontin (OPN) as a critical mediator of tissue repair during Staphylococcus aureus skin infections by analyzing single-cell transcriptomics in a murine model.

The paper shows that inhibiting UBE2N in Tregs enhances anti-tumor immunity without causing autoimmunity by converting Tregs into effector-like cells.

This study shows that UBE2N is crucial for skin homeostasis and inflammation suppression, with its loss causing inflammatory skin defects and identifying IRAK1/4 as a therapeutic target.