Stephan Speier

This study shows that the Villin-SNAP25 interaction regulates insulin secretion by controlling secretory granule docking sites in response to glucose levels.

This study investigates how GLP-1R signaling shapes β-cell heterogeneity by analyzing calcium dynamics in islets from different mouse models and humanized KO mice.

This paper generates and validates hES cell reporter lines to monitor islet-like cluster differentiation and maturation, finding that N21 supplement improves monohormonal β-cell numbers.

The paper examines islet and acinar cell secretion in different pancreatic regions across diabetes stages, finding reduced insulin secretion and beta-cell volume in T1D with normal enzyme secretion.