Frank Buchholz

The paper identifies UBP1 loss as a driver of oxaliplatin resistance in gastric cancer by revealing a compensatory reliance on translation initiation, which can be targeted with 4EGI.

This study identifies KAT2A as a therapeutic target in a subset of well-differentiated, microsatellite-stable colorectal cancers by showing its dependency and functional consequences.

This study identifies TOBF1 as a regulator of alternative splicing in mouse embryonic stem cells, showing its role in maintaining stem cell identity through co-transcriptional mechanisms.

The paper introduces RecGen, a deep learning model that generates designer-recombinases for novel DNA target sites, outperforming traditional directed evolution methods.

This study corrects a 140 kb genomic inversion in the F8 gene using a designer recombinase system, restoring Factor VIII mRNA expression in patient-derived cells.

The paper withdraws its findings on ultraconserved elements in mouse embryonic stem cells due to inconsistencies in knockout results.

The paper uses RNAi screens in isogenic human stem cells to identify SMARCA4 as a differential regulator of stemness and differentiation in hematopoietic and neural stem cells.