Melissa Kane

This study identifies viral determinants that influence neutralizing antibody production through a noncanonical pathway in gammaretroviral infections.

The paper shows that mice can control retroviral infection without TLR7 signaling, suggesting an alternative sensing pathway for immune activation.

This study shows that sequential binding of CypA and CPSF6 to HIV-1 capsid is necessary for nuclear entry and integration, and that lenacapavir targets this process.

This study shows that the RANBP2-Cyp domain influences HIV-1 infection and MX2 activity by modulating CA interactions with nucleoporins and integration targeting.

This study shows that MX2 antiviral activity depends on CypA-CA interactions and GTPase function, with loss of GTPase activity altering Nup requirements for viral restriction.