Steven Kyle Higginbottom

The paper identifies functional divergence in gut Clostridia from Hadza hunter-gatherers, revealing diet-adapted metabolic pathways that influence gut ecology.

The paper tracks gene flow in the gut microbiome, showing diet and community ecology influence phage activation and horizontal gene transfer.

The paper tracks lineage evolution and transmission of Bacteroides thetaiotaomicron across hosts and ecological scales using genomic barcoding and whole-genome sequencing.

The paper shows that T cells specific for microbiota and diet antigens predominantly become regulatory T cells (iTregs) in the gut, with effector responses emerging only under specific inflammatory and genetic conditions.

The paper identifies rare IAA-producing gut bacteria and links IAA synthesis to OFOR-driven amino acid oxidation in acetogens.

The paper shows that modifying microbial community composition, specifically overexpressing bile acid metabolic genes in Lactobacillus strains, can alter bile acid pool size and composition in mice.

The paper uses a single-strain dropout screen in a defined microbial community to show how removing specific strains affects community composition and metabolic output.

The paper develops improved mouse models of the small intestine microbiota using region-specific human intestinal sampling and in vitro culturing, showing increased diversity and reproducibility in colonization.

The paper investigates how gut microbiota modify steroidal alkaloids from Solanum plants, affecting host exposure and physiological effects.