Sean Paul Spencer

This study identifies fermentation-derived metabolites (FDMs) from fermented foods that modulate immune, microbial, and metabolic systems to reduce inflammation and metabolic disease severity.

The paper introduces MIG-Seq to analyze IgA binding to gut microbiome strains and finds that microbial genes, especially mucus degradation genes, predict IgA binding levels.

The paper develops improved mouse models of the small intestine microbiota using region-specific human intestinal sampling and in vitro culturing, showing increased diversity and reproducibility in colonization.

Nearly 500,000 cells from 24 human tissues, many from one donor, characterize over 400 cell types and enable within-donor study of T-cell clones, B-cell mutation rates and splicing.