Yuna Blum

This study shows that the constitutive androstane receptor (CAR) protects against MASLD in males through interactions with gut microbiota, but not in females.

The paper creates a single-nucleus RNA sequencing atlas of the adult chicken liver, revealing cellular composition and showing improved resolution through enhanced genome annotation.

This paper benchmarks circRNA detection tools using a simulation framework and finds they vary in performance, with limited overlap in detected circRNAs and significant computational efficiency differences.

This paper benchmarks deconvolution algorithms for multi-omic data, identifying their strengths and limitations across different conditions and data types.

This study shows hepatocyte ERα regulates sex-specific liver responses to fasting and feeding, affecting gene expression and metabolic pathways differently in males and females.

This study investigates the role of p110alpha in hepatocyte signaling, showing its critical impact on liver gene expression and its rewiring in MASLD.

Cirscan identifies differentially active circRNA sponge mechanisms and visualizes circRNA-miRNA-mRNA networks from transcriptomic data.

The paper develops an immunohistochemical panel to assess intra- and inter-tumoral heterogeneity in PDAC, identifying four distinct phenotypes with clinical implications.

DECONbench benchmarks deconvolution methods for quantifying tumor cell-type heterogeneity by providing datasets, tools, and performance evaluation.

SMAP improves sequencing analysis of xenografts by accurately mapping reads to both host and graft genomes and enhancing fusion transcript detection.