Luca Schulz

This paper introduces AlphaProtein Novo, a machine-learning pipeline for de novo enzyme design that outperforms natural sequence mining in creating enzymes for new-to-nature chemistry and substrates.

This study shows that microcystin (MC) in Microcystis aeruginosa enhances carbon fixation by activating the carbon-concentrating mechanism (CCM) and altering photosynthetic processes under fluctuating light conditions.

The paper identifies Form IF Rubiscos that are highly active, specific, and function without the small subunit, challenging the necessity of subunit complexity in Rubisco evolution.

The paper investigates the evolutionary origin of chaperone dependence in Rubisco biogenesis and finds that this dependence evolved neutrally and can be reversed without affecting catalytic function.

The paper shows that multiple mechanisms of essentiality in protein-protein interactions can persist over time, even if individual mechanisms are lost, using Rubisco as a case study.

The paper optimizes and implements reverse beta-oxidation pathways in bacteria for carbon-negative synthesis of C4-C6 acids and alcohols, achieving high product titers in engineered strains.