Sergei Sukharev

This study investigates when bacterial mechanosensitive channels activate by modeling stress distribution in the cell envelope during osmotic downshocks.

This paper distinguishes between desensitization and inactivation of MscS channels using electrophysiology and simulations, showing inactivated channels resist activation under high tension.

This paper introduces fluorescent peptide probes based on GsMTx4 to measure two-dimensional membrane tension and domain structure in biological membranes.

This paper models the conformational transition of MscS from a splayed state to a compact closed state, driven by turgor pressure and lipid synthesis, revealing a recovery mechanism for MscS-like channels.

This study investigates how different lipid species affect the function of mechanosensitive channels in E. coli, finding that cardiolipin is important for MscS adaptive behavior.

This study identifies a lipid-mediated mechanism by which the mechanosensitive channel MscS inactivates, showing that intercalated lipids physically decouple tension-sensing helices from the gate.