Andriy Anishkin

This paper distinguishes between desensitization and inactivation of MscS channels using electrophysiology and simulations, showing inactivated channels resist activation under high tension.

This paper introduces fluorescent peptide probes based on GsMTx4 to measure two-dimensional membrane tension and domain structure in biological membranes.

This paper models the conformational transition of MscS from a splayed state to a compact closed state, driven by turgor pressure and lipid synthesis, revealing a recovery mechanism for MscS-like channels.

This study identifies a lipid-mediated mechanism by which the mechanosensitive channel MscS inactivates, showing that intercalated lipids physically decouple tension-sensing helices from the gate.