Cancer BiologyCancer LettersPeer-reviewed
Anaplastic Thyroid Cancer Cells Upregulate Mitochondrial One-Carbon Metabolism To Meet Purine Demand, Eliciting A Critical Targetable Vulnerability
Adam J. Sugarman, Luong Do Huynh, Aidin Shabro, Antonio Di Cristofano
This study identifies upregulated mitochondrial one-carbon metabolism in anaplastic thyroid cancer as a targetable vulnerability, showing that inhibiting SHMT2 reduces proliferation and tumor growth.