Karine G. Le Roch

This study identifies Plasmodium NEK4 as a key regulator that couples meiotic initiation with zygote morphogenesis in malaria parasites.

The paper investigates how epigenetics and chromatin structure regulate var2csa expression and placental binding in Plasmodium falciparum, identifying H3K9me3 depletion and chromatin repositioning as key factors.

This study identifies ARK1 as a critical regulator of mitosis in Plasmodium, forming a non-canonical chromosomal passenger complex with divergent INCENPs, and highlights its potential as an antimalarial target.

The paper introduces a protein language model fine-tuned to predict antigen-specific B cell receptors from immune repertoires, showing effectiveness across multiple antigens.

This study identifies the SUN1-ALLAN complex as critical for coordinating nuclear envelope remodeling and bipartite MTOC segregation during rapid mitosis in Plasmodium male gametogenesis.

This paper identifies MED6-189, a potent antimalarial compound that disrupts apicoplast function and vesicular trafficking in P. falciparum, showing efficacy against drug-resistant strains and demonstrating a unique mechanism of action.

The paper identifies B. MO1 as a distinct Babesia species through multiomics analysis, revealing genomic and functional differences from B. divergens and insights into their evolution and virulence.

This paper identifies TgFBXL2, an F-box protein in Toxoplasma gondii, which represses feline-restricted genes required for sexual commitment by modulating SCF-E3 ubiquitin ligase activity.

The paper investigates how var2csa influences var gene expression in Plasmodium falciparum by analyzing chromatin structure changes after gene deletion.

This study shows PfMORC regulates chromatin structure and gene repression in Plasmodium falciparum, essential for parasite survival and a potential target for antimalarial drugs.

This study identifies PfAP2-MRP as a master regulator controlling parasite growth, chromatin structure, and var gene expression during malaria parasite blood stages.

This paper uses third-generation sequencing to revise the molecular karyotype of Toxoplasma gondii, identifying chromosome fusions and copy number variants in sexual recombinants.

ACCOST identifies significant changes in chromatin conformation between Hi-C experiments by accounting for the genomic distance effect, outperforming existing methods.

This study examines changes in genome organization during the transmission stages of Plasmodium parasites and finds that three-dimensional genome structure is linked to transcriptional activity of gene families involved in pathogenesis and immune evasion.