Choukri Ben Mamoun

This study evaluates acridone derivatives as potential treatments for babesiosis, finding strong in vitro activity but limited in vivo efficacy.

This study investigates whether extracellular vesicles from Babesia-infected red blood cells activate macrophages and modulate cytokine secretion.

The paper develops a fluorescence-based assay, DAB-APT, to measure aminopropyl transferase activity and inhibition, validated with enzymes from S. cerevisiae and P. falciparum.

This paper identifies MED6-189, a potent antimalarial compound that disrupts apicoplast function and vesicular trafficking in P. falciparum, showing efficacy against drug-resistant strains and demonstrating a unique mechanism of action.

The paper identifies B. MO1 as a distinct Babesia species through multiomics analysis, revealing genomic and functional differences from B. divergens and insights into their evolution and virulence.

This study screens dihydrotriazines and biguanides against Babesia and Plasmodium parasites to identify effective antifolates with broad-spectrum activity and high therapeutic indices.

This study shows that disrupting the PCA pathway in fungi affects vacuolar integrity, drug detoxification, and susceptibility to antifungal drugs, supporting its potential as a therapeutic target.