Scott A. Summers

This study identifies ceramide-driven lipotoxicity as a driver of calcific aortic valve disease and shows that SPT inhibition can reverse disease progression in vivo.

This study shows that mitochondrial cardiolipin deficiency disrupts electron transport chain function, leading to oxidative stress and promoting MASH in mice and humans.

This paper integrates clinical and transcriptomic data to identify LRRN4CL as a predictor of myocardial recovery in heart failure patients undergoing LVAD therapy, showing its association with cardiomyocyte dysfunction.

This study identifies EFHD1 as a Ca2+-dependent stabilizer of ER-mitochondrial contacts that drives liver injury in MASH by promoting mitochondrial fragmentation and antiviral stress responses.

This study identifies Bwa as a regulator of intestinal stem cell proliferation in Drosophila through pro-inflammatory cytokine signaling, linking sphingolipid metabolism to gut homeostasis.

This study integrates clinical and transcriptomic data to predict myocardial recovery in heart failure patients after LVAD implantation, identifying 80 features with an AUC of 0.731.

This study uses isotope tracing to show that β-catenin mutations in HCC suppress phosphatidylcholine synthesis while increasing fatty acid oxidation.

The paper identifies genetic drivers of plasma lipoproteins in mice and links them to human lipid traits using QTL analysis and GWAS integration.