Gregory S. Ducker

This study shows that lactate can be directly imported into mitochondria and oxidized to support cardiac energy production, independent of the pyruvate carrier.

This study shows that β-catenin activation in liver cancer cells reduces mitochondrial pyruvate carrier expression and shifts metabolism from carbohydrate to fatty acid oxidation.

This paper integrates clinical and transcriptomic data to identify LRRN4CL as a predictor of myocardial recovery in heart failure patients undergoing LVAD therapy, showing its association with cardiomyocyte dysfunction.

This study identifies miR-21 as a dysregulated microRNA in MASH-HCC, showing it promotes lipid metabolic changes that contribute to hepatocarcinogenesis in zebrafish models.

This study shows that hyperlipidemia, not obesity alone, drives breast cancer growth in mice, suggesting lipid-lowering therapies could reduce cancer risk in obese individuals.

This study investigates the mechanisms of myocardial salvage in acute myocardial infarction using left ventricular unloading and reperfusion, identifying PPARG as a key cardioprotective gene and suggesting rosiglitazone as a potential adjuvant therapy.

This study identifies SLC7A5 as essential for citrulline-dependent growth in arginine-limited conditions and shows its role in citrulline uptake and tumor growth.

This study shows that inhibiting MCT4 to redirect pyruvate metabolism reduces myocardial ischemia-reperfusion injury by improving mitochondrial function and reducing oxidative stress.

This study integrates clinical and transcriptomic data to predict myocardial recovery in heart failure patients after LVAD implantation, identifying 80 features with an AUC of 0.731.

This study uses isotope tracing to show that β-catenin mutations in HCC suppress phosphatidylcholine synthesis while increasing fatty acid oxidation.

The paper investigates how 1-carbon pathways and methylation potential in glutamatergic neurons influence alcohol sensitivity and tolerance in Drosophila.