A Characterization of Axolotl Digit Regeneration: Conserved Mechanisms, Divergent Patterning, and a Critical Role for Hedgehog Signaling
Jackson R. Griffiths, Melissa Miller, Timothy J. Duerr…·James R. Monaghan
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Northeastern UniversityORCID 0000-0002-4945-0294Unclaimed ORCID profile · follow to get notified of new preprints
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7 papers
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Jackson R. Griffiths, Melissa Miller, Timothy J. Duerr…·James R. Monaghan
Vineel Kondiboyina, Melissa Miller, Maren Ritterbuck…·Sandra J. Shefelbine
The paper investigates the role of TRPV4 and PIEZO2 in axolotl limb regeneration, finding that TRPV4 inhibition reduces limb length without affecting cartilage differentiation.
Quentin A. Meslier, Timothy J. Duerr, Webster Guan…·Sandra J. Shefelbine
WISH-BONE labels osteocyte mRNA and protein in 3D adult mouse bones, enabling spatially preserved biomarker expression analysis.
Timothy J. Duerr, Melissa Miller, Sage Kumar…·James R. Monaghan
This study shows that retinoic acid breakdown via CYP26B1 determines positional identity during amphibian limb regeneration, with Shox playing a key role in PD skeletal element formation.
Ester Comellas, Johanna E. Farkas, Giona Kleinberg…·Sandra J. Shefelbine
The paper investigates how mechanical stimuli influence joint morphogenesis by combining experimental and computational approaches in axolotl limb regeneration.
Timothy J. Duerr, Eun Kyung Jeon, Kaylee M. Wells…·James R. Monaghan
The paper generates a transgenic axolotl line expressing FUCCI to study cell cycle dynamics during tissue regeneration.
Timothy J. Duerr, Ester Comellas, Eun Kyung Jeon…·James R. Monaghan
This paper develops a method to visualize and quantify macromolecule synthesis in vivo using click chemistry and light sheet microscopy, demonstrating its sensitivity to biological perturbations.