Jonathan D. G. Jones

This study investigates the oligomerization and activation mechanism of the RPS4-RRS1 immune receptor complex in Arabidopsis, showing that effector recognition triggers conformational changes that enable NADase activity.

The paper identifies two resistance genes from Solanum americanum that confer resistance to Phytophthora pathogens and shows their NLR cluster evolves in response to multiple pathogens.

The paper identifies Rladg, a potato TIR-NLR receptor that confers broad-spectrum resistance to poleroviruses by recognizing conserved protease structures.

The paper shows that NLR immune receptor architecture enforces EDS1-dependency on diverse TIR domains in plants.

The paper identifies a conserved glycoside hydrolase family in leaf rust fungi that interacts with barley LecRKs to mediate non-host resistance, showing functional conservation across cereal species.

This study identifies NRG1 as a plant NLR receptor that targets chloroplasts to trigger immunity by channeling stromal calcium into the cytosol, revealing a novel mechanism for organelle-specific immune signaling.

Activated wheat CCG10-NLR immune receptor WAI3 and Arabidopsis RPS2 assemble into octameric calcium-permeable resistosomes with an inverted coiled-coil domain topology associated with lacking the conserved EDVID motif.

This study determines the structural basis of broad recognition by the Arabidopsis NLR WRR4A, revealing a shape-based mechanism that enables recognition of diverse effectors with similar three-dimensional architectures.

This study characterizes tuber and starch properties in diploid potato lines and their hybrids, showing variation in starch structure and yield traits.

The paper identifies structural features that confer heat tolerance in plant NLR immune receptors and enables in silico classification and engineering of temperature-tolerant variants.

This study uncouples hypersensitive cell death from disease resistance in plants by showing that HR is not essential for effective immunity.

The paper profiles ETI responses across Arabidopsis leaf cell types using single-cell transcriptomics and finds cell-type-specific immune module activation.

The paper demonstrates that co-transferring sensor and helper NLRs from Solanaceae to rice, soybean, and Arabidopsis can extend immune receptor functionality across plant families.

The paper identifies non-membrane-tethered RIN4 fragments generated by AvrRpt2 that activate RPS2, requiring NDR1 and overcoming suppression by the membrane-tethered C-terminal fragment.

This study shows that OGOX enzymes regulate oligogalacturonide levels, affecting plant immunity and tissue repair by balancing active OGs and oxidized oxOGs.

This study identifies two distinct signalling modules in Arabidopsis that mediate different aspects of effector-triggered immunity, with implications for improving disease resistance in crops.

This study engineers pattern recognition receptors to enhance broad-spectrum resistance in plants, showing improved efficacy in tomato, rice, and poplar.

The paper identifies a ubiquitination-deubiquitination cycle regulating the stability and function of the paired NLR receptor complex RRS1/RPS4 in Arabidopsis.

This study identifies the Avr gene Avramr1 from Phytophthora infestans using long-read and cDNA pathogen-enrichment sequencing, revealing key insights into effector evolution and polymorphism.

This paper clones four stem rust resistance genes in wild diploid wheat using association genetics and R gene enrichment sequencing within six months.

The paper develops NLR-Annotator to identify NLR genes in wheat genomes and characterizes their structure, phylogeny, and expression, finding 3,400 NLR loci with 88% low basal expression.

The paper develops a method to map structural variants as quantitative traits in Arabidopsis, identifying transpositions and their phenotypic effects using low-coverage sequencing data.