Tolga O. Bozkurt

The paper shows that the helper NLR NRC4 detects effector-induced changes in TOPGAP activity, leading to immune activation.

This study shows that NbRD21 protease regulates receptor-like kinase homeostasis in Nicotiana benthamiana by affecting their post-translational processing and endocytic recycling.

This study identifies NRG1 as a plant NLR receptor that targets chloroplasts to trigger immunity by channeling stromal calcium into the cytosol, revealing a novel mechanism for organelle-specific immune signaling.

View Tomo improves cryoET by enabling 3D analysis and targeting through low-dose, rapid tomogram acquisition and automated processing.

This paper introduces VULCROM, a vacuum-free cryogenic fluorescence microscope that enables high-resolution cryo-SR-CLEM and detailed single-molecule studies in vitrified specimens.

The study identifies a hydrophobic core in the coiled-coil domain of NRCs that is essential for their function in immunity.

This study identifies AGO10 as a key player in trans-species RNA interference in plant immunity, showing its role in pathogen gene silencing and immune response.

This study identifies two phospholipases, LCAT3 and LCAT4, that work together to hydrolyze autophagic bodies in plant cells, completing the autophagy pathway.

AlphaFold 3 oligomer models separate paired plant NLRs: helpers score higher pTM and form funnel-shaped resistosomes unlike sensors, including some rice pairs lacking integrated-domain annotations.

This paper identifies an effector from Phytophthora infestans that bridges NbTOL9a to an activated NLR to suppress immunity, revealing a novel structural and functional mechanism.

The paper visualizes calcium signaling and organelle dynamics during resistosome-mediated cell death in plants, revealing a sequential cascade of subcellular events.

The paper identifies immunity genes that suppress transient protein expression in Nicotiana benthamiana by silencing them and observing increased GFP expression.

This study determines the structure of sensor-activated NbNRC2 using cryo-EM, revealing a hexameric resistosome and highlighting structural changes during NLR activation.

This study shows how the helper NLR NRC2 converts from a homodimer to a higher-order oligomer upon activation by the sensor NLR Rx, revealing the molecular mechanism of plant immune activation.

This paper introduces TETRIS, an electrochemical platform to monitor NaCl uptake in tomato seedlings, revealing differences in salt tolerance among genotypes and growth conditions.

The paper uses AF2-multimer to accurately predict both canonical and atypical ATG8 binding motifs in proteins, including those in pathogens and plant hosts.

The paper shows that during P. infestans infection, ATG8CL autophagosomes are diverted to the pathogen interface, suggesting the pathogen coopts host selective autophagy.

The study identifies NRC3 as required for Pto-mediated cell death in N. benthamiana, while NRC1 is not, using genome annotation, phylogenetics, and genetic experiments.

This paper shows that the P. infestans effector AVR3a suppresses BAK1/SERK3-mediated immunity by reducing FLS2 endocytosis and associating with DRP2, a GTPase involved in receptor-mediated endocytosis.