Author

Jean E. Schaffer

Joslin Diabetes CenterORCID 0000-0002-4954-6659Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Abigael CheruiyotiD· 1 shared Aiden McCarty· 1 shared Allison Carroll· 1 shared Arlette Cabral· 1 shared Brooke Sullivan· 1 shared Emma Johnson· 1 shared Hui PaniD· 1 shared Jennifer Hollister‐LockiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

Abigael CheruiyotORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintNov 22, 2025

Kruppel-like factor 1 acts upstream of the SKN-1/Nrf transcription factors to modulate oxidative stress, lipid homeostasis and longevity

Jorge Iván Castillo-Quan, Aiden McCarty, Ugne Kurdeikaite…·Natalie Moroz

This study identifies KLF-1 as an upstream regulator of SKN-1/Nrf transcription factors in C. elegans, linking lipid homeostasis, oxidative stress, and longevity.

DOI 10.1101/2025.11.22.689963

C. elegansexperimental assay

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Cell BiologyJournal of Clinical InvestigationPeer-reviewedNov 30, 2023

Sustained hyperglycemia specifically targets translation of mRNAs for insulin secretion

Abigael Cheruiyot, Jennifer Hollister‐Lock, Brooke Sullivan…·Jean E. Schaffer

This study shows that sustained high glucose reduces translation of mRNAs involved in insulin secretion in beta-cells, impairing their function.

19 citations

mousehuman

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