Author

Jennifer Hollister‐Lock

Joslin Diabetes CenterORCID 0000-0003-4469-4932Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:Ribo-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Brooke Sullivan· 2 shared Susan Bonner‐WeiriD· 2 shared Abigael CheruiyotiD· 1 shared Alexander Lee-Papastavros· 1 shared Andy Ma· 1 shared Hui PaniD· 1 shared Jean E. SchafferiD· 1 shared Jessica da Silva Pereira· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersGenetics

Brooke Sullivan

Mutual co-authors in cluster

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2 papers

Recent·Most cited

GeneticsbioRxivPreprintMay 13, 2024

Loss-of-function of ALDH3B2 transdifferentiates human pancreatic duct cells into beta-like cells

Jian Li, Kevin Bode, Yu‐Chi Lee…·Yi Peng

This study shows that knocking out ALDH3B2 in human pancreatic duct cells converts them into beta-like cells that function and reduce blood glucose in mice.

DOI 10.1101/2024.05.13.593941

humanCRISPR screen

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Cell BiologyJournal of Clinical InvestigationPeer-reviewedNov 30, 2023

Sustained hyperglycemia specifically targets translation of mRNAs for insulin secretion

Abigael Cheruiyot, Jennifer Hollister‐Lock, Brooke Sullivan…·Jean E. Schaffer

This study shows that sustained high glucose reduces translation of mRNAs involved in insulin secretion in beta-cells, impairing their function.

19 citations

mousehuman

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