Matthew J. Flick

This study shows that AQP4 regulates edema, maintains astrocyte differentiation, and limits immunosuppressive changes in glioblastoma.

This study identifies extravascular coagulation as a regulator of fibrotic stromal states in PDAC via tumor-intrinsic PAR1 signaling, showing PAR1 inhibition can reprogram the tumor-promoting stroma.

This study creates a mouse model with a thrombin-insensitive PAR4 receptor, showing reduced thrombosis but normal responses to PAR4 agonists.

This study evaluates POmAb, an anti-prothrombin antibody, in mice showing it reduces thrombin generation and fibrin formation without excessive bleeding.

This study shows that fibrin accumulation in a catheterized bladder promotes anti-inflammatory macrophage polarization, which impairs antimicrobial responses and allows bacterial persistence in UTIs.

This study uses 4D intravital imaging to show platelets, not endothelial cells, are the main procoagulant surface during hemostatic plug formation in mice.