Nigel Mackman

This study creates a mouse model with a thrombin-insensitive PAR4 receptor, showing reduced thrombosis but normal responses to PAR4 agonists.

This study shows that PAR4 deficiency reduces atherosclerosis in Ldlr-/- mice, with effects mediated by hematopoietic cells, particularly platelets, and highlights differences in platelet reactivity between apoE-/- and Ldlr-/- models.

This study identifies discrete inflammatory signatures driving thrombosis in the spleen and liver after Salmonella infection, revealing both organ-specific and shared mechanisms.

This study shows that platelet inhibition increases rupture risk in early abdominal aortic aneurysm models in mice.