Aaron Embry

This study identifies ISG20 and its bacterial homologs as interkingdom antiviral factors that restrict both bacterial RNA phages and human RNA viruses through UTR trimming.

This study identifies RNF214 as a mammalian antiviral factor using bacterial effectors, showing its role in restricting arbovirus infection through ubiquitination-mediated degradation.

This study shows RNA viruses, like DNA viruses, are restricted by the FEAR pathway and have evolved distinct mechanisms to counteract it by targeting SUMOylated Spt16 proteins.

The paper identifies evolutionarily conserved host factors that restrict arbovirus replication by using bacterial effector proteins to rescue viral replication in insect cells.