Neal M. Alto

The paper identifies ELMO2 as a specific target of Shigella IpaH4.5 ubiquitin ligase, revealing divergence in ELMO paralogs and their functional roles in bacterial infection.

The paper identifies IL32 as a cytokine that targets intracellular pathogens via the N-degron pathway and autophagy, revealing a mechanism by which IFN-gamma signaling mediates host defense against pathogens like Chlamydia.

This study shows that the CCC complex regulates PI(3)P levels on phagosomal membranes, which is critical for phagosome maturation and antibacterial immunity.

This study identifies ISG20 and its bacterial homologs as interkingdom antiviral factors that restrict both bacterial RNA phages and human RNA viruses through UTR trimming.

This paper introduces SidBait, a modular proximity ligation approach to identify small molecule and protein targets, validated with known interactions and applied to discover new targets like CaMKII and CapZ.

The paper uses multimutant Salmonella strains to identify SPI-2 effector functions in gut inflammation and systemic colonization, finding SopD2 and GtgE critical for mucosal pathology.

This study uses genome minimization and single-cell mass cytometry to identify effector genes in Salmonella that drive pathogen dissemination between immune cells.

This study identifies RNF214 as a mammalian antiviral factor using bacterial effectors, showing its role in restricting arbovirus infection through ubiquitination-mediated degradation.

This study shows Shigella flexneri uses IpaH1.4 to degrade RNF213 and prevent LPS ubiquitylation, evading host antibacterial autophagy.

This study identifies IpaH1.4 as a Shigella effector that degrades RNF213, preventing ubiquitylation of intracellular bacteria and evading host immunity.

The paper identifies evolutionarily conserved host factors that restrict arbovirus replication by using bacterial effector proteins to rescue viral replication in insect cells.