Georg Sebastian Hönes

This study shows short-term T3 treatment improves cardiac function after MI in WT mice, while long-term T3 causes hypertrophy without functional benefit and may worsen function in TR-deficient mice.

The paper shows that thyroid hormone and resmetirom have harmful extrahepatic effects in white adipose tissue that counteract their beneficial effects on the liver in alcohol-associated liver disease in mice.

This study identifies the complete sequences of pathogenic and non-pathogenic FGF14 repeat expansions in patients with cerebellar ataxia, revealing a lower pathogenic threshold and providing mechanistic insights into disease causation.

This study compares TRα and TRβ knockout mice with DNA-binding-deficient mutants to show noncanonical TR signaling contributes to physiological functions beyond canonical genomic pathways.

This study shows that thyroid hormone-induced cardiac hypertrophy relies on noncanonical TR action, while heart rate regulation depends on canonical TR action, with TRβ compensating for TR absence.

This study shows that thyroid hormone levels do not significantly affect cardiac recovery in old mice with preexisting pressure-induced cardiac damage.