ALK Inhibition Prolongs Survival in a Mouse Model of ALK-positive Anaplastic Thyroid Cancer
Yara Maria Machlah, Tim Brandenburg, Georg Sebastian Hönes…·Lars Christian Moeller
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Essen University HospitalORCID 0000-0002-9330-9036Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
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Yara Maria Machlah, Tim Brandenburg, Georg Sebastian Hönes…·Lars Christian Moeller
Susanne Camilla Grund, Stefanie Dörr, Georg Sebastian Hönes…·Dagmar Führer
This study shows short-term T3 treatment improves cardiac function after MI in WT mice, while long-term T3 causes hypertrophy without functional benefit and may worsen function in TR-deficient mice.
Christoph Hoppe, Georg Sebastian Hönes, Adrian D. Prinz…·Lars Christian Moeller
The paper shows that thyroid hormone and resmetirom have harmful extrahepatic effects in white adipose tissue that counteract their beneficial effects on the liver in alcohol-associated liver disease in mice.
Philippa Spangenberg, Sebastian Bessler, Lars Widera…·Daniel Robert Engel
msiFlow automates and streamlines multimodal mass spectrometry imaging and immunofluorescence data analysis to enhance reproducibility and scalability in biological research.
Georg Sebastian Hönes, Daniela Geist, Christina Wenzek…·Lars Christian Moeller
This study compares TRα and TRβ knockout mice with DNA-binding-deficient mutants to show noncanonical TR signaling contributes to physiological functions beyond canonical genomic pathways.
Daniela Geist, Georg Sebastian Hönes, Susanne Camilla Grund…·Lars Christian Moeller
This study shows that thyroid hormone-induced cardiac hypertrophy relies on noncanonical TR action, while heart rate regulation depends on canonical TR action, with TRβ compensating for TR absence.
Riccardo Dore, Sarah Christine Sentis, Kornelia Johann…·Jens Mittag
This study shows that TR{beta}-KO mice exhibit partial resistance to thyroid hormone-induced tachycardia and cardiac hypertrophy when studied at thermoneutrality.
Helena Kerp, Janina Gassen, Susanne Camilla Grund…·Dagmar Führer
This study shows that thyroid hormone levels do not significantly affect cardiac recovery in old mice with preexisting pressure-induced cardiac damage.