Katherine Y. King

BESTish infers mutation fitness, mutation rate, and environmental strength in clonal hematopoiesis using a diffusion-approximation framework applied to VAF datasets.

This study identifies let-7 as a regulator of AT2 cell differentiation and fibrosis prevention by controlling oncogenic networks and epigenetic changes.

This study examines clonal dynamics and somatic evolution in mouse haematopoiesis, finding that stem cells accrue mutations at a rate similar to human progenitors and exhibit distinct age-related patterns.