Daniel J. Tschumperlin

The paper integrates single-cell RNA sequencing and spatial transcriptomics to identify CTHRC1+ fibroblasts as key fibrogenic cells in IPF, showing how culture affects their transcriptional profile.

This study identifies MPO as a post-translational inhibitor of CatK, linking acute inflammation to sustained fibrosis through impaired collagen degradation.

This study shows the SOCS domain reduces ECM protein accumulation in fibrotic lung myofibroblasts and experimental lung fibrosis by inhibiting collagen and fibronectin fibril formation.

This study shows that Tenascin-C promotes early lung cancer progression by activating integrins and FAK in mouse models and human lung adenocarcinomas.

The paper identifies a redox-shifted fibroblast subpopulation in fibrotic lungs, showing increased pro-fibrotic activity and reduced collagenolytic activity.

This study shows that inhibiting SLC1A5, a glutamine transporter, reduces fibrosis by altering fibroblast metabolism and function in a mouse model of lung fibrosis.