Author

Tianling Ou

Broad InstituteORCID 0000-0002-5119-2239Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Charles C. BaileyiD· 2 shared Gogce C. CryneniD· 2 shared Michael FarzaniD· 2 shared Wenhui HeiD· 2 shared Yiming YiniD· 2 shared Andi PaniD· 1 shared Baodan Hu· 1 shared Brian D. QuinlaniD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBioengineering

Charles C. BaileyORCID

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2 papers

Recent·Most cited

BioengineeringNature Biomedical EngineeringPeer-reviewedDec 5, 2024

In vivo affinity maturation of the HIV-1 Env-binding domain of CD4

Andi Pan, Charles C. Bailey, Tianling Ou…·Wenhui He

This study demonstrates that non-antibody protein biologics can undergo affinity maturation in vivo, leading to improved binding affinity and neutralization potency against HIV-1.

15 citations

mouseproteomics

𝕏 PostBluesky

BioengineeringNature Biomedical EngineeringPeer-reviewedMar 14, 2024

In vivo affinity maturation of murine B cells reprogrammed to express human antibodies

Yiming Yin, Yan Guo, Yuxuan Jiang…·Michael Farzan

This study demonstrates that CRISPR-edited murine B cells expressing human antibodies can undergo affinity maturation, generating potent neutralizing antibodies against HIV-1 and SARS-CoV-2.

24 citations

mouseproteomics

𝕏 PostBluesky