Andrew G. Deighan

This study investigates how the gut microbiome interacts with aging and dietary restriction in mice, finding that host genetics significantly influence microbiome features and that dietary restriction does not rejuvenate the microbiome.

In 937 genetically diverse female mice, caloric restriction and intermittent fasting extended lifespan, yet bodyweight resilience, immune and red-cell traits, not metabolic improvements, predicted longevity.

The paper quantifies diet-dependent genetic contributions to body weight in mice and identifies loci associated with age- and diet-dependent body weight variation.

The paper analyzes transcriptome and proteome data from aged mouse hearts to identify molecular changes associated with aging, revealing distinct biological processes and genetic loci influencing age-related changes.

This study examines how caloric restriction and intermittent fasting interact with genetics to influence physiological health in mice, finding diet-specific effects and significant genetic contributions to multiple traits.