Koen C. Oost

The paper identifies how cell heterogeneity and YAP1 inactivation drive tissue patterning during intestinal regeneration through feedback mechanisms.

This paper creates a human endoderm organoid cell atlas by integrating single-cell transcriptomes from multiple organoid types to compare cell states with primary tissues and disease models.

This study develops a model to culture human intestinal organoids and identifies two stem cell states crucial for regeneration and lineage balance.

The paper introduces a dual-view light sheet microscope for live imaging of large multicellular systems at single-cell resolution and demonstrates its use on intestinal organoids and gastruloids.