Ariën Schiepers

This study investigates how booster immunizations affect germinal center (GC) clonality in mice, finding that refueling leads to clonal expansion rather than memory recruitment.

The paper shows mosaic-8b nanoparticles induce broader cross-reactive antibodies than homotypic ones, even in pre-vaccinated animals, suggesting potential for improved vaccine design against emerging sarbecoviruses.

This study investigates how pre-existing antibodies and memory T cell help influence the dynamics of recall germinal centers, showing that pre-existing antibodies suppress antigen binding while memory T cells enable B cells to access GCs despite low antigen binding.