Shayan Sarkar

This study identifies K17 as a marker of an EMT-associated migratory cell state in PDAC, showing its role in promoting tumor-cell migration and poor prognosis.

This study identifies continuous spatial organization of immune composition and tumor identity in pancreatic cancer using spatial transcriptomics and single-cell imaging.

This study determines the cryo-EM structure of HP1 bound to an H2A.Z nucleosome, revealing two binding sites and their roles in transcriptional repression and chromatin compaction.

This study establishes a murine model of age-dependent Powassan virus (POWV) lethality, revealing divergent neuroinflammatory cytokine responses in young and old mice that correlate with CNS viral clearance and disease severity.