Jennifer L. Young

This study shows enzymatic remodeling of aged cardiac ECM reduces stiffness but preserves contractility and some age-related transcriptional features in ex vivo myocardial slices.

This study shows that increased ovarian ECM stiffness with age impairs follicle function by reducing granulosa cell proliferation and oocyte quality through TGF-β signaling.

This study investigates mechanical memory in cells, showing that stiffness-sensitive cells improve confined migration after prior exposure to soft substrates, mediated by NFATC2.

This study investigates how theca cell mechanosensing and extracellular matrix properties regulate ovarian follicle development in mice.

This study shows that 3D matrix stiffness affects CAF morphology and drug response in breast cancer by altering mechanotransduction and transcriptional programs.

The paper develops tunable hybrid scaffolds to study how ligand presentation and mechanical stiffness in ECM influence cardiac fibroblast behavior during aging.