Xingyu Shen

This study shows that increased ovarian ECM stiffness with age impairs follicle function by reducing granulosa cell proliferation and oocyte quality through TGF-β signaling.

The paper develops tunable hybrid scaffolds to study how ligand presentation and mechanical stiffness in ECM influence cardiac fibroblast behavior during aging.

This study shows that exposing aged oocytes to a young follicular environment improves their maturation, developmental potential, and mitochondrial function.