Danny David Jonigk

This study transplants human iPSC-derived cardiomyocyte aggregates into non-human primates with myocardial infarction, showing efficient engraftment and functional recovery with lower cell doses than previous single-cell approaches.

This study uses single-cell and spatial transcriptomics to identify structural cell circuits in BOS lungs and their spatial organization during airway obliteration.

This study identifies aberrant cell populations in RAS lungs using snRNA-seq and histology, revealing a fibrotic niche composed of specific cell types with potential therapeutic targets.

This paper presents the first single-nucleus RNA sequencing atlas of pleuroparenchymal fibroelastosis, identifying novel cell states and their spatial organization in lung fibrosis.

The Human Organ Atlas provides open access to multiscale 3D imaging of human organs, along with tools and resources for analysis and research.

This study uses multimodal single-cell profiling to identify immune cell crosstalk mechanisms in poor prognostic cholangiocarcinoma, revealing key ligand pairs and pathways contributing to immune exhaustion.

This paper demonstrates the application of Hierarchical Phase-Contrast Tomography (HiP-CT) in three biomedical case studies, revealing detailed organ structures at multiple scales.

This study shows that the TNKS inhibitor OM-153 reduces fibrosis markers and ECM expression in multiple preclinical IPF models by inhibiting WNT/β-catenin and YAP signaling.

This study creates a spatial transcriptomics atlas of human tuberculosis and non-tuberculous mycobacterial granulomas, identifying distinct niches and immune signatures.

This paper identifies PMVEC alterations in IPF using single-cell RNA sequencing and spatial transcriptomics, develops endothelial injury models, and validates functional assays for drug discovery.

This study shows that removing B cell-derived IL-10 increases resistance to tuberculosis in mice, with stronger effects in males.

This paper demonstrates HiP-CT's ability to image adult human hearts at multiple scales, revealing structural details in health and disease.

The paper uses cultured human alveolar basal cells to create in vitro and in vivo models that mimic honeycomb cyst formation in idiopathic pulmonary fibrosis.

The paper uses spatial transcriptomics to identify novel pathologic niches in IPF lung tissue and their cellular composition and communication.

This study shows camostat mesylate inhibits SARS-CoV-2 by blocking TMPRSS2 and its metabolite GBPA also has antiviral activity, suggesting no resistance through TMPRSS2-related proteases.