Simone Reber

The paper investigates the relationship between nuclear density and function across eukaryotes, finding that nuclear import, not transcription, determines density in some organisms.

The paper shows that protein-driven osmotic pressure regulates nuclear size and function, affecting chromatin organization and gene expression in yeast, human, and fly cells.

This study introduces QuPID-MS to measure protein phase separation in cells, showing weak interactions drive proteome demixing and influence environmental response.

This study shows how Tau condensates age into elastic networks with inhomogeneous polymerization and seed formation, providing mechanistic insight into their transition to pathological aggregates.

The paper introduces a synthetic dataset for microtubule segmentation and evaluates automated methods, finding that a foundation model achieves near-perfect performance when guided by synthetic data.

This study identifies how Plasmodium tubulin adaptations lead to distinct microtubule structures, mechanics, and drug susceptibility compared to mammalian microtubules.

The paper investigates how cytoplasmic density changes during cell differentiation and how this affects mitotic spindle architecture and scaling.

This study uses differential dynamic microscopy to analyze cytoplasmic dynamics in Xenopus laevis egg extracts and HeLa cells, revealing subdiffusive motion and cytoskeletal influences on fluidity.

This study investigates how temperature adaptation in microtubule dynamics is achieved through sequence changes in tubulin from three frog species.

This study shows that the nuclear-to-cytoplasmic density ratio is conserved across eukaryotes and drives cellular organization, with implications for diseases like cancer and senescence.

The paper introduces Spindle3D, a tool for analyzing 3D spindle morphology, and finds that spindle width best predicts spindle volume across cell types and species.