David H. Spencer

The paper identifies intermediate methylation regions in normal cells as epimutation hotspots in cancer, showing they are prone to clonal epimutations in leukemia and other cancers.

The paper introduces a high-throughput microplate-based CUT&Tag protocol for parallel processing of 96 samples, achieving comparable quality to benchtop methods.

This study profiles genomic and immunogenomic features of eAML, finding clonal branching and immune editing, with FLT3 mutations in relapsed cases.

This study shows that MBI MYC mutations alter MYC localization and disrupt mRNA subcellular distribution and turnover, promoting leukemogenesis.

This study tracks clonal dynamics in human haematopoiesis across age, finding that clonal diversity sharply declines after 70, driven by positive selection on many genes and loss of Y chromosome in males.

The paper identifies a GRCh38 reference sequence change that prevents detection of U2AF1 mutations and provides a modified reference to address this issue.

The paper investigates the role of CTCF binding in regulating HOXA gene expression in NPM1-mutant AML cells and finds that transcriptional activity does not require long-range CTCF-mediated chromatin interactions.