Yitao Tang

This paper shows that combining IRE with anti-PD-1 induces abscopal effects in PDAC by triggering immune activation and systemic antitumor responses.

This study shows ZNF397 loss leads to TET2-driven epigenetic changes, lineage plasticity, and resistance to AR-targeted therapies in AR-dependent cancers, with TET2 inhibitors reversing resistance.

This study shows that FASlpr gene dosage affects lymphoproliferation and T cell differentiation in lupus models, with heterozygous Faslpr leading to increased autoantibodies and Th1 cell skewing.

GuidePro integrates multiple predictive methods to prioritize sgRNAs for CRISPR/Cas9 protein knockouts, showing consistent performance across datasets.

The paper compares CRISPR/Cas9-based targeted capture methods with whole genome sequencing for detecting structural variants in CHO cell lines, finding that CRISPR/Cas9 reduces sequencing artifacts but lacks completeness for complex rearrangements.