Angela M. Major

This study investigates the dual role of the CXCL10-CXCR3 axis in osteosarcoma, showing it promotes tumor growth but also recruits immune cells, suggesting CXCR3 inhibition could target metastasis.

This study evaluates the long-term combination therapy of metformin and oxymetholone in Fancd2-/- mice, finding no synergistic effect but improved HSC quiescence and partial gene expression normalization with metformin alone.

This study develops an ex vivo CRISPR gene editing protocol for hepatocytes to treat hereditary tyrosinemia type 1, showing successful engraftment and disease correction in mice.

This study shows that FASlpr gene dosage affects lymphoproliferation and T cell differentiation in lupus models, with heterozygous Faslpr leading to increased autoantibodies and Th1 cell skewing.