Geoffrey Ian McFadden

The paper identifies mutations in apicoplast rRNA genes linked to clindamycin resistance in malaria parasites and shows these mutations reduce mosquito infectivity.

This study optimizes an mRNA vaccine to enhance liver Trm cell induction by reducing type I interferon responses through improved manufacturing.

The paper identifies temporal expression patterns of liver-stage malaria antigens and shows that combining antigens with different temporal profiles improves vaccine efficacy.

The paper shows Vγ1+ γδ T cells produce IL-4 to activate DC and CD8 T cells, enhancing immunity against Plasmodium.

This study shows that RAS vaccination generates long-lived liver-resident memory T cells specific for abundant sporozoite antigens, which mediate protection but may limit vaccine efficacy against diverse parasite strains.

The paper identifies aryl amino acetamides that inhibit Plasmodium falciparum ring development by targeting PfSTART1, a lipid transfer protein, and shows these inhibitors block parasite transmission.

The paper shows that azithromycin resistance in malaria parasites reduces their transmission via mosquitoes, suggesting it could help control drug resistance.

This study identifies MMV020291 as a compound that targets actin-1/profilin dynamics in Plasmodium falciparum, inhibiting red blood cell invasion and apicoplast segregation.