Krzysztof Pawłowski

The paper identifies YfiM and AT1G15900 as LLO pyrophosphatases in E. coli and Arabidopsis, revealing a conserved quality control mechanism across prokaryotes and plants.

This study identifies DUF4062 as TIR-like NADases involved in bacterial antiphage defense and eukaryotic RNA vault function through structural and biochemical analyses.

This paper introduces SidBait, a modular proximity ligation approach to identify small molecule and protein targets, validated with known interactions and applied to discover new targets like CaMKII and CapZ.

This study identifies ACAD10 as encoding two enzymes involved in ether lipid biosynthesis and salvage, linking them to type 2 diabetes risk.

The paper identifies NCI-2, a covalent inhibitor of the SARS-CoV-2 NiRAN domain, and presents a structural blueprint for drug design.

This paper identifies potential drug targets and predicts treatment efficacy and resistance in melanoma subtypes using proteogenomic data and drug sensitivity analysis.

This study identifies C12orf29 as an RNA ligase that ligates tRNA and alters tRNA levels in mice, with structural insights into its catalytic mechanism.

The paper identifies 63 ART-like proteins in 41 Legionella species, organized into 39 families, including 26 novel ones, and proposes a database for further study.

The paper identifies six proteins that predict response to immune checkpoint therapy across three melanoma cohorts and correlate with patient survival.

The paper identifies a novel ADP-ribosyltransferase family conserved across eukaryotes, suggesting a role in innate immune signaling through ADP-ribosylation.