Diana R. Tomchick

The paper identifies DancE, a bacterial cGAS-like enzyme activated by DNA, and shows its regulation by DnaK and activation by lambda phage protease gpC.

This study identifies DUF4062 as TIR-like NADases involved in bacterial antiphage defense and eukaryotic RNA vault function through structural and biochemical analyses.

This paper introduces SidBait, a modular proximity ligation approach to identify small molecule and protein targets, validated with known interactions and applied to discover new targets like CaMKII and CapZ.

This study identifies a domain-swapped conformation in CaMKII that enables linker-mediated allosteric regulation, demonstrated through structural, computational, and live-cell analyses.

This study identifies ACAD10 as encoding two enzymes involved in ether lipid biosynthesis and salvage, linking them to type 2 diabetes risk.

This study identifies C12orf29 as an RNA ligase that ligates tRNA and alters tRNA levels in mice, with structural insights into its catalytic mechanism.

The paper identifies evolutionarily conserved host factors that restrict arbovirus replication by using bacterial effector proteins to rescue viral replication in insect cells.