Keitaro Yamashita

The paper shows how two reverse transcriptases with different templating strategies work together to produce complementary DNA for antiviral defense.

This study reveals the structural mechanism of the type IX Retron-Kva2 anti-phage defense system in Klebsiella variicola, showing how it cleaves host RNAs to inhibit phage infection.

The paper demonstrates atomic resolution cryo-EM at 200 kV using upgraded hardware, achieving 1.24 Å resolution comparable to 300 kV systems.

This paper introduces a Bayesian method to estimate atomic scattering factors from cryo-EM data, improving accuracy by incorporating molecular environment effects.

This study determines the structure of TbAQP2 bound to drugs and glycerol, revealing how mutations in the channel lead to drug resistance in Trypanosoma brucei.

This study reports six LAT1 structures bound with ligands, revealing substrate recognition and inhibition mechanisms, including the role of JPH203 as an anticancer drug.

This paper extends the REFMAC5 program in the CCP4 suite to refine macromolecular models using neutron crystallographic data, improving the accuracy of hydrogen atom localization.

The paper reports the presence of abundant Aβ fibrils in aqueous extracts from Alzheimer's disease brains, with structures identical to those in amyloid plaques.

This study reports cryo-EM structures of human EAAT2 in substrate-free and inhibitor-bound states, revealing structural features and the mechanism of selective inhibition.

The paper presents cryo-EM structures of CALHM channels from different species, revealing their ATP conduction and oligomerization mechanisms.

The paper reports X-ray structures of the human ETB receptor bound to agonists, revealing molecular mechanisms of activation and partial agonism.