Dong I. Lee

This study shows that in vivo bioincubation of human iPSC-derived cardiomyocytes in neonatal rat and pig hearts promotes maturation to adult-like phenotypes with organized sarcomeres and mature morphology.

This study identifies nuclear GAPDH translocation as a mediator of stress-induced cardiac hypertrophy through BRG1-associated chromatin remodeling in mice and human patients.

This study shows that in vivo maturation of MLP-KO iPSC-CMs recapitulates DCM phenotypes, while in vitro maturation does not.

This study identifies PGC1/PPAR signaling and its regulators Yap1 and SF3B2 as key drivers of cardiomyocyte maturation through single-cell transcriptomic analysis across neonatal to adult hearts.