Samantha Beck Previs

This paper identifies UCB-9721 as a potent inhibitor of T. gondii MyoA, showing greater potency than KNX-002 and inhibiting related apicomplexan parasites.

This study investigates how kinesin-1 autoinhibition affects cargo transport through 3D microtubule intersections, showing that autoinhibited motors reduce MT engagement and alter directional outcomes.

This study investigates the functional role of MyBP-H in developing vertebrate fast-twitch skeletal muscle using zebrafish and rat models, revealing its involvement in myofilament lattice compression and contractility regulation.

This paper studies how kinesin-1 motors transport liposome cargo through 2D and 3D microtubule intersections, finding that spatial relationships bias directional outcomes, with a higher straight-through rate at 3D intersections.

The paper identifies mutations in MYLPF causing segmental amyoplasia with distal arthrogryposis, showing both dominant and recessive inheritance patterns and linking MYLPF impairment to muscle degeneration.

This study uses single-molecule microscopy to show that the C0C3 fragment of cMyBP-C enhances myosin binding at low calcium but blocks it at high calcium, suggesting a role in calcium sensitization.