BioengineeringNature Cardiovascular ResearchPeer-reviewed
A Drug-Elicitable Alternative-Splicing Module (DreAM) for Tunable AAV Expression and Controlled Myocardial Regeneration
17 citationstop 2%
Author
Zhan Chen
Peking UniversityORCID 0000-0002-5542-675XUnclaimed ORCID profile · follow to get notified of new preprints
Biology Disciplines
Click to filter author papersSignature Assays, Organisms & Methods
Click to filter · or open tagApproach:experimental assay· 5Organism:mouse· 5Research Focus:gene regulatory network inference· 3Research Focus:cell type annotation· 2Research Focus:drug response / drug discovery· 2Research Focus:cell signaling & trafficking· 1Research Focus:cell-cell communication· 1Research Focus:differential expression· 1
Activity by Year
2023-2025 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 45 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship5 papers
Recent·Most cited
- Molecular BiologybioRxivPreprint
An all-in-one AAV vector for cardiac-specific gene silencing by an adenine base editor
Zhanzhao Liu, Luzi Yang, Yuhan Yang…·Yuxuan Guo
This study shows that single-AAV delivery of base editors can achieve effective cardiac gene silencing with higher success rates than dual-AAV systems.
3 citations - Cell BiologyJACC Basic to Translational SciencePeer-reviewed
Non-cell autonomous cardiomyocyte regulation complicates gene supplementation therapy for LMNA cardiomyopathy
Yueshen Sun, Congting Guo, Zhan Chen…·Yuxuan Guo
This study shows that gene supplementation for LMNA cardiomyopathy is ineffective when targeting cardiomyocytes alone, as non-cell autonomous effects dominate, suggesting alternative therapeutic targets.
7 citations - PhysiologybioRxivPreprint
Myocardial infarction creates a critical time window for AAV gene therapy
Gonglie Chen, Yueyang Zhang, Zhan Chen…·Yuxuan Guo
This paper shows that myocardial infarction creates a time window where AAV gene therapy is more effective in mice, improving gene expression and therapeutic outcomes when administered three days post-infarction.
DOI 10.1101/2024.06.10.597311 - PhysiologybioRxiv
MicroRNA-122-mediated liver detargeting enhances the tissue specificity of cardiac genome editing
Luzi Yang, Zhanzhao Liu, Gonglie Chen…·Yuxuan Guo
This study shows that AAV-Tnnt2 vectors leak into the liver, reducing cardiac specificity, and demonstrates that adding miR122 target sequences reduces this leakiness.
DOI 10.1161/circulationaha.123.065438