Dongyu Zhao

The paper benchmarks protein interaction models to distinguish direct partners from non-binding or noncontacting proteins, showing that context recognition and direct specificity are separable capabilities.

The paper identifies cancer driver lncRNAs by analyzing their association with cancer driver genes and topologically associated domains, revealing 256 oncogenic, 177 tumor suppressive, and 75 dual-function lncRNAs.

This study shows neural organoids protect engineered heart tissues from glucolipotoxicity by transferring versican, identified through co-culture experiments and functional assays.

POCALI identifies cancer lncRNAs by integrating 44 multi-omics features, showing improved sensitivity and strong associations with cancer phenotypes.

This study shows that single-AAV delivery of base editors can achieve effective cardiac gene silencing with higher success rates than dual-AAV systems.

This study shows that gene supplementation for LMNA cardiomyopathy is ineffective when targeting cardiomyocytes alone, as non-cell autonomous effects dominate, suggesting alternative therapeutic targets.

The paper introduces MACMIC, a method to identify feature pairs with maximal colocalization and minimal correlation, revealing CTCF's dual role in regulating cell identity genes through epigenetic mechanisms.