Hao Sun

caRBP-Pred predicts chromatin-associated RNA-binding proteins using short peptide sequences, achieving an AUC of 0.81 and identifying 52 potential caRBPs in mice.

This study uses spatial transcriptomics to analyze MDA5+ dermatomyositis muscles, revealing distinct transcriptomic profiles, immune cell infiltration, and vascular inflammation.

The paper evaluates imputation performance in East and Southeast Asian populations, showing that recent selection affects variant detection and polygenic risk score estimation.

This study uses single-nucleus multiomics to characterize senescence in human skeletal muscle, identifies SASP factors, and proposes Maraviroc as a senotherapeutic for sarcopenia.

This study shows that skeletal muscle stem cells modulate their niche in Duchenne muscular dystrophy via the YY1-CCL5 axis, influencing macrophage and fibro-adipogenic progenitor behavior and offering a therapeutic target.

PathoEye is a deep learning framework for analyzing whole-slide skin images, focusing on the dermis-epidermis junction to identify features of skin diseases and aging.

This study identifies RNA binding proteins (RBPs) as key regulators of TAD organization through their enrichment at TAD boundaries and synergistic interaction with nascent transcripts.

This study shows DHX36 binding remodels RNA structure, particularly in 3UTRs, leading to decreased mRNA abundance via m6A and YTHDF1 interactions.

This study identifies YTHDC1 as a critical regulator of muscle stem cell activation and proliferation by modulating mRNA splicing and nuclear export during regeneration.

This study identifies PAM-1, a long non-coding RNA that regulates skeletal muscle satellite cell activation and aging by trans-regulating Timp2 expression with Ddx5.

This study develops a CRISPR/Cas9/AAV9-sgRNA system for in vivo genome editing in muscle satellite cells to investigate key transcription factors during activation and regeneration.