Yang Li

The paper identifies a senescent-like muscle stem cell subpopulation that drives muscle regeneration through secretory activity and cell communication.

This study maps G-quadruplexes in skeletal muscle stem cells and shows their role in promoting activation and regeneration through chromatin looping and transcription factor binding.

This study uses single-nucleus multiomics to characterize senescence in human skeletal muscle, identifies SASP factors, and proposes Maraviroc as a senotherapeutic for sarcopenia.

This study shows that skeletal muscle stem cells modulate their niche in Duchenne muscular dystrophy via the YY1-CCL5 axis, influencing macrophage and fibro-adipogenic progenitor behavior and offering a therapeutic target.